LymphedemaV1, Main, Exploration, bibRecord, 005672

Quantitative Imaging of Lymphatic Function with Liposomal Indocyanine Green

Identifieur interne : 005672 ( Main/Exploration ); précédent : 005671; suivant : 005673

Quantitative Imaging of Lymphatic Function with Liposomal Indocyanine Green

Auteurs : Steven T. Proulx ; Paola Luciani ; Stefanie Derzsi ; Matthias Rinderknecht ; Viviane Mumprecht ; Jean-Christophe Leroux ; Michael Detmar

Source :

Cancer Research [ 0008-5472 ] ; 2010.

RBID : PMC:3398157

Descripteurs français

KwdFr :
- Agents colorants (administration et posologie), Animaux, Facteur de croissance endothéliale vasculaire de type C (biosynthèse), Injections intradermiques, Liposomes (administration et posologie), Mélanome expérimental (), Mélanome expérimental (anatomopathologie), Mélanome expérimental (métabolisme), Métastase lymphatique, Souris, Souris de lignée C57BL, Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (métabolisme), Vert indocyanine (administration et posologie).
MESH :
- administration et posologie : Agents colorants, Liposomes, Vert indocyanine.
- anatomopathologie : Mélanome expérimental, Vaisseaux lymphatiques.
- biosynthèse : Facteur de croissance endothéliale vasculaire de type C.
- métabolisme : Mélanome expérimental, Vaisseaux lymphatiques.
- Animaux, Injections intradermiques, Mélanome expérimental, Métastase lymphatique, Souris, Souris de lignée C57BL.

English descriptors

KwdEn :
- Animals, Coloring Agents (administration & dosage), Indocyanine Green (administration & dosage), Injections, Intradermal, Liposomes (administration & dosage), Lymphatic Metastasis, Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Melanoma, Experimental (blood supply), Melanoma, Experimental (metabolism), Melanoma, Experimental (pathology), Mice, Mice, Inbred C57BL, Vascular Endothelial Growth Factor C (biosynthesis).
MESH :
- chemical , administration & dosage : Coloring Agents, Indocyanine Green, Liposomes.
- chemical , biosynthesis : Vascular Endothelial Growth Factor C.
- blood supply : Melanoma, Experimental.
- metabolism : Lymphatic Vessels, Melanoma, Experimental.
- pathology : Lymphatic Vessels, Melanoma, Experimental.
- Animals, Injections, Intradermal, Lymphatic Metastasis, Mice, Mice, Inbred C57BL.

Abstract

Lymphatic vessels play a major role in cancer progression and in postsurgical lymphedema, and several new therapeutic approaches targeting lymphatics are currently being developed. Thus, there is a critical need for quantitative imaging methods to measure lymphatic flow. Indocyanine green (ICG) has been used for optical imaging of the lymphatic system but it is unstable in solution and may rapidly enter venous capillaries after local injection. We developed a novel liposomal formulation of ICG (LP-ICG), resulting in vastly improved stability in solution and an increased fluorescence signal with a shift towards longer wavelength absorption and emission. When injected intradermally to mice, LP-ICG was specifically taken up by lymphatic vessels and allowed improved visualization of deep lymph nodes. In a genetic mouse model of lymphatic dysfunction, injection of LP-ICG showed no enhancement of draining lymph nodes and slower clearance from the injection site. In mice bearing B16 luciferase expressing melanomas expressing vascular endothelial growth factor-C (VEGF-C), sequential near infrared imaging of intradermally-injected LP-ICG enabled quantification of lymphatic flow. Increased flow through draining lymph nodes was observed in mice bearing VEGF-C expressing tumors without metastases while a decreased flow pattern was seen in mice with a higher lymph node tumor burden. This new method likely will facilitate quantitative studies of lymphatic function in preclinical studies and may also have potential for imaging of lymphedema or improved sentinel lymph detection in cancer.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398157

DOI: 10.1158/0008-5472.CAN-10-0271
PubMed: 20823159
PubMed Central: 3398157

Affiliations:

Le document en format XML

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<author><name sortKey="Derzsi, Stefanie" sort="Derzsi, Stefanie" uniqKey="Derzsi S" first="Stefanie" last="Derzsi">Stefanie Derzsi</name>
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<term>Injections, Intradermal</term>
<term>Liposomes (administration & dosage)</term>
<term>Lymphatic Metastasis</term>
<term>Lymphatic Vessels (metabolism)</term>
<term>Lymphatic Vessels (pathology)</term>
<term>Melanoma, Experimental (blood supply)</term>
<term>Melanoma, Experimental (metabolism)</term>
<term>Melanoma, Experimental (pathology)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Vascular Endothelial Growth Factor C (biosynthesis)</term>
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<term>Facteur de croissance endothéliale vasculaire de type C (biosynthèse)</term>
<term>Injections intradermiques</term>
<term>Liposomes (administration et posologie)</term>
<term>Mélanome expérimental ()</term>
<term>Mélanome expérimental (anatomopathologie)</term>
<term>Mélanome expérimental (métabolisme)</term>
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<term>Souris</term>
<term>Souris de lignée C57BL</term>
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<term>Vaisseaux lymphatiques (métabolisme)</term>
<term>Vert indocyanine (administration et posologie)</term>
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<term>Indocyanine Green</term>
<term>Liposomes</term>
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<term>Liposomes</term>
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<front><div type="abstract" xml:lang="en"><p id="P2">Lymphatic vessels play a major role in cancer progression and in postsurgical lymphedema, and several new therapeutic approaches targeting lymphatics are currently being developed. Thus, there is a critical need for quantitative imaging methods to measure lymphatic flow. Indocyanine green (ICG) has been used for optical imaging of the lymphatic system but it is unstable in solution and may rapidly enter venous capillaries after local injection. We developed a novel liposomal formulation of ICG (LP-ICG), resulting in vastly improved stability in solution and an increased fluorescence signal with a shift towards longer wavelength absorption and emission. When injected intradermally to mice, LP-ICG was specifically taken up by lymphatic vessels and allowed improved visualization of deep lymph nodes. In a genetic mouse model of lymphatic dysfunction, injection of LP-ICG showed no enhancement of draining lymph nodes and slower clearance from the injection site. In mice bearing B16 luciferase expressing melanomas expressing vascular endothelial growth factor-C (VEGF-C), sequential near infrared imaging of intradermally-injected LP-ICG enabled quantification of lymphatic flow. Increased flow through draining lymph nodes was observed in mice bearing VEGF-C expressing tumors without metastases while a decreased flow pattern was seen in mice with a higher lymph node tumor burden. This new method likely will facilitate quantitative studies of lymphatic function in preclinical studies and may also have potential for imaging of lymphedema or improved sentinel lymph detection in cancer.</p>
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<name sortKey="Proulx, Steven T" sort="Proulx, Steven T" uniqKey="Proulx S" first="Steven T." last="Proulx">Steven T. Proulx</name>
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Serveur d'exploration sur le lymphœdème

Quantitative Imaging of Lymphatic Function with Liposomal Indocyanine Green

Quantitative Imaging of Lymphatic Function with Liposomal Indocyanine Green

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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